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3 It has been surmised that the etiology of asymptomatic and transient abnormalities in the aminotransferases of affected patients may be the result of changes in hepatocyte lipid membranes leading to an increase in its permeability and leakage of liver enzymes

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However, the widespread adoption of organoid and OoC models remains constrained by technical complexity, reproducibility and standardisation challenges, scalability issues, and evolving regulatory frameworks [177]

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