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As a target of let-7 family, IGF-1R can promote the cell proliferation through the crosstalk between IRS-2/Akt and MAPK pathways 46,47

However, despite NBS and subsequent early diagnosis and treatment, some patients still develop severe symptoms, including fatal metabolic derangements [21, 62, 63]

In: De, LJ G, JL J, editors

His liver and kidney functions showed total bilirubin 7.36 mg/dL, conjugated bilirubin 4.69 mg/dL, blood urea 159 mg/dL, and serum creatinine 4 mg/dL, suggesting acute hepatocellular failure and acute kidney injury

PRP is an autologous blood fraction rich in platelets and their associated growth factors (GFs)