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While the study concluded that short-term DSIP treatment was unlikely to be of major therapeutic benefit noting that statistically significant effects were weak and partly attributable to incidental placebo group change it provided the most methodologically rigorous human sleep architecture dataset for DSIP and confirmed the compounds specific effect on objective, not merely subjective, sleep quality parameters

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Blood flow is directed to the digestive system rather than allowing the body to shift into rest-and-repair mode

If something reduces the function of any of the organs that break down the B12, then the amount utilised can be even less