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The CD36-mediated component of GHRP-2s cardioprotection is mechanistically consistent with the extensively characterised cardioprotective activity of GHRP-6 and Hexarelin, with whom GHRP-2 shares the CD36 pharmacophore scaffold

Epilepsy induces the upregulation of mGluR5 expression, and reducing the expression of mGluR5 may be a potential strategy for the treatment of epilepsy

Clinical trials and meta-analyses indicate that berberine significantly reduces total cholesterol, LDL, and triglycerides (while raising HDL) in patients with dyslipidemia, an effect partly due to upregulation of LDL receptor expression in the liver and modulation of AMPK-dependent lipid metabolism