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oleifera has been widely assessed in both in vitro and in vivo models to evaluate potential cytotoxicity and systemic toxicity associated with various extracts

Primary keratinocyte culture is limited by their variability in culture conditions, and their susceptibility to irritants varies with the number of passages

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Besides that, GPx3 knock-down results in a decreased proliferation, synthesis of DNA and increased apoptosis in spermatogonial stem cells in men [24]

It encourages the differentiation of macrophages into pro-fibrotic M2 phenotypes and an increase in extracellular matrix synthesis, which exacerbates renal fibrosis