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Patient selection for clinical trials should reflect the pathophysiologic subtype of hyperuricemia, existing comorbidities, and concurrent use of urine alkalization agents such as potassium citrate

Obesity, poor diet, and a sedentary lifestyle are major contributors to gout, and individuals with diabetes or insulin resistance are at a higher risk of developing the condition

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Common mild side effects include gastrointestinal symptoms

Disruptions in the gut microbiome can adversely affect the absorption and metabolism of critical micronutrients, including iodine and selenium, thereby influencing thyroid hormone synthesis and immune regulation