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Additional proposed mechanisms include interaction with NMDA receptors and modulation of the stress and HPA axis , the hypothalamic-pituitary-adrenal system that governs the body's stress response

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Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF-B, and MCP-1 in patients with coronary artery disease: A randomized placebo-controlled clinical trial