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CPP-CAND disrupts FOXO4-p53 foci and induces apoptosis through caspase-dependent pathways FOXO4 is progressively recruited to euchromatin foci following senescence induction and is retained in the nucleus of senescent cells through its interaction with p53, contributing to the maintenance of the senescent state 34

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The microspheres are thus prepared by any method which produces microspheres in a size range acceptable for use in an injectable formulation or composition

BadgleyMAKremerDMMaurerHCDelGiornoKELeeH-JPurohitVet al