Although it has been heralded as a revolutionary treatment for both diabetes and obesity, its effects on brain activity tell a more complex tale regarding emotional well-being and hunger control
61,94 These cells are known to actively survey the CNS environment to orchestrate changes to maintain brain homeostasis, meet changing physiological needs, and respond to pathological events by serving as brain immune cells to coordinate innate immune responses
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Hyperglycemia enhances platelet activation and high-shear stressinduced activation, leading to arterial thrombosis, partly due to acute enhancement of the circulating levels of von Willebrand factor (Stegenga et al., 2006), nonenzymatic glycation of platelet glycoproteins, changes in their conformation and membrane lipid structure alterations ( On the other hand, hypoglycemia, which is the main adverse effect of insulin therapy, also appears to be associated with platelet activation
