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In vitro studies in HK2 An immortalized proximal tubule epithelial cell line from normal adult human kidney HK-2 (ATCC CRL-2190) was used for in vitro assays

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In cartilage research, a 2015 study in a collagenase-induced knee osteoarthritis rabbit model showed that combined AOD-9604 and hyaluronic acid injections were significantly more effective than either treatment alone, with treated groups showing lower gross morphological and histopathological scores