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The misuse-abuse of fentanyl causes adverse effects including opioid-induced respiratory depression (OIRD) 1

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Importantly, holotranscobalamin, the fraction of vitamin B 12 available for tissue uptake, was reported to remain relatively stable throughout pregnancy after a decline in early gestation (Reference Murphy, Molloy and Ueland57,Reference Greibe, Andreasen and Lildballe59)

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Niacinamide assists here too, as it is a precursor to NAD+, and that makes this pathway especially interesting for anyone curious about longevity and cellular energy