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Rotating between different injection sites each week reduces the risk of lipodystrophy, a condition where repeated injections in the same spot can cause dents or thickened tissue under the skin

Mild soreness, redness, or tenderness at the injection site may occur temporarily

Side Effects & Safety No lethal dose found -- toxicology studies couldn't establish an LD50 (Sikiric et al., 2006) No organ toxicity in chronic dosing No hormonal effects -- doesn't affect testosterone, estrogen, cortisol, or GH Mild nausea -- mostly with oral dosing Brief lightheadedness -- occasionally after injection Injection site redness -- standard for SC peptides Angiogenesis concern -- promotes new blood vessel growth, which raises a theoretical question about existing tumors

Some of the biochemical pathways that affect psychiatric symptoms are directly impacted by excess copper in the system

doi:10.1074/jbc.R113.458810