However, currently the use of GLP-1 RAs is not recommended as treatment of MASLD.(3) The American Diabetes Association 2025 guidelines similarly state GLP-1 RAs are recommended in adults with diabetes, obesity, and MASLD in combination with diet and exercise for weight loss
In patients diagnosed with anxiety or bipolar disorder, it could stabilize mood and improve cognitive response to stress
All clinical claims in this article were fact-checked through OpenEvidence, an AI medical literature service, prior to publication
Their effects likely arise from a convergence of pathways: indirectly, through systemic improvements in glycemic control and metabolism, and directly, via the activation of intraocular GLP-1Rs on cells like retinal Mller and ganglion cells, which triggers local anti-inflammatory, anti-oxidant, and anti-apoptotic responses
Beneficial for Restricted Diets especially for those following vegetarian, vegan, or other restricted diets that may lack sufficient B12
