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Differential modulation of the androgen receptor for prostate cancer therapy depends on the DNA response element

Other sources of superoxide can be enzymatic reactions that transfer electrons to the ETC such as mitochondrial glycerol 3-phosphate dehydrogenase (mGPDH), and the last step of -oxidation, electron-trasferring flavoprotein ubiquinone oxidoreductase (ETFQOR) or dehydrogenases such as pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxoacid dehydrogenase (BCKDH)

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Individual responses may differ, and some may experience effects sooner or later

Additionally, metabolic adaptation is real: your body slightly reduces energy output when calories drop, a protective mechanism from evolution