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Retrieved from Pratama, K
GLP-1 agonists directly bind these receptors, triggering insulin secretion, slowing gastric emptying, and increasing satiety
It provides appetite suppression, delayed gastric emptying, and glucose homeostasis through a single receptor pathway
The key finding was that plasma concentrations in patients taking 8 mg of retatrutide (approximately 182 nanomolar) exceeded the effective concentrations observed in the laboratory, suggesting these cardiac effects are clinically relevant at therapeutic doses
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