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Notably, these results agree with a recent review confirming the safety and effectiveness of the ALA and GLA combination for improving DPN [133]

This, in turn, leads to reduced brain tryptophan concentration, decreased 5-HT levels, and diminished 5-HT receptor binding, which may underlie the 5-HT system dysfunction, impaired neurotransmission, and negative cognitive effects observed in SZ

PMC 2836803

This imbalance interferes with the body's ability to detoxify the cellular microenvironment, fold proteins, replenish antioxidants, maintain healthy immune responses and even modulate apoptotic events, promoting suboptimal cellular function and development of diseases

Metformin biodistribution: a key to mechanisms of action