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184 Zinc Zinc serum levels have been observed as lower in people with migraine, 185,186 and this may have clinical relevance as zinc is essential for a wide range of neurological functions relevant to migraine

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As such, it is involved in many biological processes, including the breakdown of fats, the reduction of serum cholesterol, serotonin activity modulation, gene expression, and insulin signal transduction

To remove the Rosa26 Cre locus, Rosa26 Cre:Glp-1r / offspring were crossed with wild-type C57BL/6 mice to obtain Glp-1r +/ offspring that were used as breeders to generate all cohorts for these studies