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In the Teichman study, the DAC form produced multi-fold increases in GH and a durable rise in IGF-1 lasting many days after a single dosea powerful pharmacological effect that also explains the plausibility of GH-related side effects

In clinical studies, a greater number of people who took Saxenda for 56 weeks lost 5 to 10% of their body weight, compared with people who took a placebo

However, the prevalence of impaired glucose intolerance, T2DM or metabolic syndrome in PWS tends to be lower when compared to that in obese controls (as presented in Table 1) [4, 10, 11]

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Am J Physiol Endocrinol Metab 2005;289:E670-E677