DOI 10.21007/con.dnp.2026.0149 Faculty Advisor Bobby Bellflower, DNSc, NNP-BC, FAAN, FAANP, FNAP Subject Matter Expert Jordan Isaac Clinical Site University of Tennessee Health Science Center Document Type Poster Publication Date Spring 5-3-2026 Disciplines Investigative Techniques | Medicine and Health Sciences | Nursing | Quality Improvement Abstract Purpose/Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for diabetes and obesity due to their metabolic benefits
Among those is SPP, which forms a complex with DERL1 and TRC8 to cleave XBP1u, a translation product of unspliced XBP1 RNA that negatively regulates the UPR
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Indeed, the formation of both GSTP1-JNK and GSTP1-1-TRAF2 complexes were described in vivo