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The 0.25 mg dose is doing its job if you are tolerating it and noticing appetite changes, even if the scale has barely moved

Others sleep through without issue

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A paper published this week in JAMA Psychiatry found semaglutide, the active ingredient in GLP-1 drugs like Ozempic and Wegovy, "significantly improved" motivation in patients with major depressive disorder, or MDD a promising finding because lack of motivation and related disruptions to the brains reward pathways play a critical role in many other psychiatric conditions as well

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