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Figure 2 4.3.2 Amplification of immune responses by released intracellular components following ferroptosis When ferroptosis leads to the rupture of chondrocytes or synovial cells, the oxidized lipid byproducts, iron ions, and damage-associated molecular patterns (DAMPs) that leak from these cells are detected by nearby immune cells

The leukotrienes and prostaglandins promote the release of substance P and calcitonin gene-related peptide (CGRP) from the nociceptive fibers into the microenvironment