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Abstract Keloids are pathological scars exhibiting tumour-like aggressiveness and high recurrence rate

The mechanisms include blood pressure reduction, improvement in lipid profiles, anti-inflammatory effects on the arterial wall, and possible direct cardioprotective effects through GLP-1R expressed on cardiomyocytes

Discussion We report 3 probands from two unrelated families with rare BBOX1 variants, L-carnitine deficiency, and elevated levels of plasma -BB, indicative of a causative effect of the BBOX1 variants affecting the final stage of the L-carnitine biosynthetic pathway

Research in men, erectile dysfunction, broader libido enhancement, and other populations remains investigational

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