Comparators were varied and included placebo (6 studies), insulin formulations (10 studies), metformin (9 studies), and other oral antidiabetic drugs (OADs) such as sulfonylureas, DPP-4 inhibitors, and acarbose (12 studies)
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Pernicious anemia is associated with an increased incidence of carcinoma of the stomach, but this is believed to be related to the underlying pathology and not to treatment with cyanocobalamin