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Subjects were supplemented with either a placebo or a combination of the antioxidants vitamin C and NAC

doi:10.1177/00034894211018921

Additionally, PARP inhibitors (PARPi) demonstrate significant clinical efficacy in BRCA-mutated patients (124), but emerging resistance limits their long-term effectiveness (125), Patients may develop resistance through multiple mechanisms, such as secondary BRCA gene mutations or restoration of DNA repair pathways (126)

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VDAC1, as one of the most abundant integral membrane proteins on the outer mitochondrial membrane, has a critical role in cellular energy exchange 63