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Liraglutide (Victoza) followed in 2010, semaglutide (Ozempic) in 2017, oral semaglutide (Rybelsus) in 2019, semaglutide for weight loss (Wegovy) in 2021, and the first GIP/GLP-1 dual agonist tirzepatide (Mounjaro) in 2022 with its weight-loss sibling Zepbound in 2023

Despite these differences in inducible defense, bacterial growth as a measure of disease resistance proved to be similar in inoculated younger and older leaves (Zeier, 2005)