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At the 2 AR and the CXCR4, detailed mapping of intracellular phosphorylation sites by mass spectrometry defined distinct sites for phosphorylation by individual GRKs, which were associated with distinct functions of -arrestins [95, 96]

The degree of this downregulation correlates positively with the severity of cartilage degeneration, being most pronounced in advanced lesions characterized by surface fibrillation and severe proteoglycan loss (Miao et al., 2022

This determined that cell death begins to be detected after 4 days of age, and that our interventions with SIH and Lip-1 completely suppressed this cell death at 6 and 8 days of age (Figure 2C)