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Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation

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Patients should: Stay well hydrated Eat smaller, more frequent meals Avoid high-fat, greasy, or very spicy foods if experiencing nausea Report persistent or severe symptoms to their prescriber When to seek medical advice: Contact your GP or diabetes team for: Persistent vomiting or diarrhoea Concerns about medication effects or side effects Symptoms of hypoglycaemia if taking other diabetes medications Contact NHS 111 or seek urgent care for: Severe, persistent vomiting preventing fluid intake Signs of dehydration (dark urine, dizziness, reduced urination) Severe or persistent abdominal pain, particularly if radiating to the back (potential pancreatitis) Pain in the right upper abdomen, yellowing of skin/eyes (potential gallbladder issues) Sudden vision changes Allergic reactions (rash, difficulty breathing, facial swelling) Most patients find that side effects diminish significantly after 812 weeks, and the benefits of appetite control and metabolic improvement become more apparent

A positive response was obtained in the in vivo micronucleus assay in mice