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IGF-1 LR3 bypasses that entire regulatory sequence and acts directly on tissue-level IGF-1 receptors, which is why research describes its signaling onset as faster and more direct than secretagogue-based approaches, though also more potent at the receptor level

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Comparison of independent and combined metabolic effects of chronic treatment with (pGlu-Gln)-CCK-8 and long-acting GLP-1 and GIP mimetics in high fat-fed mice