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The STEP 5 trial extended this data, showing sustained weight loss of 15.2 percent over 104 weeks

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In a mouse model with full-thickness articular cartilage defects created on the trochlear groove using a 26G needle, catalpol contributes to cartilage regeneration, bone structure improvement, and increased matrix anabolism by stimulating endogenous mesenchymal stem cells (MSCs) in the cartilage, thus promoting the repair of localized cartilage defects (Wu et al., 2024a)

Reconstitute with sterile bacteriostatic water or appropriate laboratory buffer Add solvent slowly along the vial wall to minimize foaming Gently swirl until the peptide is dissolved Store reconstituted solutions at 3646 F (28 C) Prepare aliquots where appropriate to reduce freezethaw cycles Careful reconstitution supports peptide stability and preserves functional integrity in experimental systems