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Zinc chelators, such as prostaglandins, glutathione, pancreatic secretions, tripeptides, amino acids, and organic acids, can promote its absorption

The cyclic structure enhances stability and receptor selectivity compared to its parent compound

cellular uptake is then mediated by ZIP (Zrt/Irt-like Protein) importers and ZnT exporters whose coordinated activity maintains nanomolar cytosolic concentrations while permitting millimolar sequestration in secretory vesicles-regulation that is crucial during stresses such as burns or sepsis when requirements rise markedly

Indeed, the EC-derived organoids were found to replicate patient- and tumor-specific responses to drugs, an observation which was further expanded to discover patient-specific drug efficacy (personalized medicine) at higher throughput [70, 71]