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The mechanistic logic is solid even though the human study has not been done Reduce exposure where you can: do not heat food in plastic containers, switch to glass or stainless steel

Mechanistic studies revealed that this effect is mediated by the ubiquitin-proteasome system and depends on covalent engagement of cysteine 98 (Cys98) in the E3 ligase FBXO28 through its acrylamide warhead

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