doi: 10.1016/j.ccell.2018.03.017 Summary Keywords ferroptosis, iron metabolism, skin diseases, melanoma, psoriasis Citation Wang K, Lin Y, Zhou D, Li P, Zhao X, Han Z and Chen H (2024) Unveiling ferroptosis: a new frontier in skin disease research
Binders are natural substances that are claimed to bind to so-called toxins in the body so that they dont spill all over our insides and trigger an immune reaction, or worse, get reabsorbed into the body before they can be eliminated
It is essential for the function of macrophages, the cells responsible for clearing away spent neutrophils before they can undergo NETosis
Conclusions and perspectives Despite all the controversy in this space, the general consensus is that irAEs are not a pre-requisite for ICI benefit but rather a positive heralding sign of clinical benefit
It has FDA approval, multiple large randomized controlled trials, and a defined prescribing label