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247 Mechanistically, it is unclear how GLP-1-based therapies exert beneficial effects on the cardiovascular system, but studies have suggested that this is achieved by direct (cardiovascular GLP-1R activation) and indirect (promotion of the incretin effect) mechanisms

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University of Southern California researchers estimated in a 2023 study that GLP-1 coverage would save Medicare up to $245 billion in 10 years if private insurers also covered the drugs

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