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Oral Microbiome Defense Antimicrobial Peptides LL-37 Histatins Human Beta-Defensins What is it
They are not recommended in those with personal or family history of multiple endocrine neoplasia 2A, multiple endocrine neoplasia 2B, or medullary thyroid cancer due to concern for long-term thyroid effects.3 Side Effects and their Implications in the ED Gastrointestinal Side effects Mild gastrointestinal side effects are most common with patients experiencing nausea (25-40%), vomiting, diarrhoea, or constipation.3,4 Rarer, more serious presentations include pancreatitis, bowel obstruction, gallbladder disease, which should be actively managed in the ED.3,5 Hypersensitivity reaction These reactions are commonly associated with self-limiting or antihistaminic responsive pruritic rash
Sometimes the fix is not a medication switch but a lifestyle recalibration
NICE guideline NG198
While NAMPT activators show promise in preclinical studies, they are yet to enter clinical trials
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