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Restoring B12 levels can have a significant impact on improving mood and mental health

Exogenous GABA Alleviates Tourette Syndrome-Like Behavior in SD Rats by Maintaining Striatal Metabolic Homeostasis The gut-brain axis is important in maintaining homeostasis, 20 particularly as striatal metabolic alterations may contribute to TS progression

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Additionally, asymmetric dimethylarginine (ADMA), an endogenous inhibitor of eNOS, competes with L-arginine for binding, reducing NO synthesis ( 2+ channels in VSMCs (Smith et al., 2020), triggering depolarizing Ca 2+ spikes in VSMCs leading to vasoconstriction (Ng et al., 2024)