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I think that you are right in suggesting that pain and increased ventricular lactate in FM may have a different mechanistic underpinning (than in ME/CFS) and a strong candidate is neuroinflammation

Several other studies have also provided evidence that GLP-1RA can reduce hepatic fat accumulation and reduce steatosis in liver tissue by regulating the expression of genes and proteins related to the fat synthesis pathway [109,110]

( 10 ) While theyre typically not as powerful for weight loss as GLP-1 medications, they can be a useful complement to diet and exerciseespecially for men dealing with low energy or sluggish metabolism, though clinical studies supporting significant weight loss are limited

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