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When medically appropriate, testosterone replacement can complement training and nutrition efforts, particularly during GLP-1-induced weight loss, which can sometimes reduce endogenous testosterone levels due to caloric restriction and fat loss

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Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA, Shiffman ML, Clore JN (2001) Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities