The cardiovascular protection observed in these trials likely results from multiple mechanisms: weight loss itself, direct effects on inflammation, improved blood vessel function, and favorable changes in lipid levels all working together to reduce disease risk
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As shown in Table 3, only the beneficial and no-effect scores were found, although in five studies vitamin E supplementation was above the UL of 300 mg/day and in one study, vitamin E supplementation was even above the UL of 1,000 mg/day
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(2026) discuss the evaluation framework for acquired oral hyperpigmentation broadly, and smoking history would typically be part of any comprehensive clinical assessment of oral pigmentation
