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SS: Data curation, Investigation, Methodology, Validation, Visualization, Writing original draft

BMAL1 forms heterodimers with CLOCK to drive the transcription of core clock-controlled genes such as PERS, CRYS and DBP (Mendoza-Viveros et al., 2017), and consistently, HRD1 overexpression significantly reduces PER1 and DBP mRNA levels, suggesting downstream transcriptional suppression via BMAL1 destabilization (Guo et al., 2020)

Bibcode:2017JFung...3...44B

Creatine monohydrate is the most studied and trusted form of creatine, consistently shown to enhance exercise performance and muscle growth

To detect MIM in the EV fractions from FBS, the PVDF membrane was incubated with anti-MIM antibody in Can Get Signal Solution 1 (TOYOBO, #NKB-201) overnight at 4 C and then with HRP-conjugated anti-mouse IgG antibody in Can Get Signal Solution 2 (TOYOBO, #NKB-301) overnight at 4 C