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Mice then received an intraperitoneal bolus of 2 mg/g D-Glucose (Sigma-Aldrich) for glucose tolerance tests (GTT), 0.75 IU/kg of human insulin (Actrapid 100 IU/mL, Novo Nordisk) for insulin tolerance tests (ITT) or 2 g/kg pyruvate (Sigma-Aldrich) for pyruvate tolerance tests (PTT) as in ( ad libitum access to water throughout the experiment

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