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Proper refrigerated storage: Store in main refrigerator section (not freezer) Keep away from freezer compartment (avoid freezing) Don't store in door (temperature fluctuates) Protect from light (keep in box or wrap in foil) Label with reconstitution date Signs of degradation: Cloudiness or particles (should be clear) Color change (should remain same color as when mixed) Unusual odor Loss of effectiveness If you notice any of these, discard and prepare fresh solution

Mild cloudiness may sometimes improve after the vial rests at a stable temperature or after gentle swirling

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Since 1990s, with the discovery of TRP channels, our understanding about nociception has changed

Typical doses are 75150 mg per day , usually split into two doses