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Some patients may experience mild redness or tenderness at the injection site

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Le Semax activates the CREB (cAMP Response Element-Binding protein) signaling pathway in hippocampal neurons, leading to increased transcription of the BDNF gene

[15] Serious but infrequent events-such as angioedema, bronchospasm, hypotension, or urticaria-reflect IgE-mediated hypersensitivity and may require desensitization or substitution with hydroxocobalamin