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The metabolic effects of AKI within the kidney are well-described: disruption of mitochondrial structure, dynamics, biogenesis, and basic electron transport chain function are all present 36

The acetylation-modulating capacity of butyrate positions it as a promising therapeutic candidate in treating cancer, inflammation, and neurological diseases (Table 1)

Similarly, other small molecule inhibitors and antibody-drug conjugates are being tested in other types of cancers where the IGF-1R/PI3K and AXL signaling pathways have also recently attracted attention, including in primary bone cancers where they play a major role in oncogenesis, cell differentiation and fate, metastasis, and drug resistance (53)

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