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Exposure to extreme heat or freezing temperatures can degrade its effectiveness

Heat stress activates thermoregulatory mechanisms (increased cardiac output, sweating), but uncompensated fluid/electrolyte loss induces mild illnesses (heat syncope, cramps, exhaustion) or severe heat stroke (HS) [3, 4]

Therapeutic category/Drug classification Semaglutide Injection is a prescription-only injectable medicine

93 Glutamatergic hyperactivity with its ensuing excitotoxicity and oxidative stress are also thought to play a role, making NAC a potential treatment option

The 4-PBA group showed mild sinusoidal congestion with focal hepatocyte necrosis as manifested by nuclear pyknosis, karyorrhexis, and karyolysis with cytoplasmic eosinophilia (Figure 8A), yet it significantly attenuated histopathological scoring compared to MTX-group (Figures 8BD)