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In April 2026, The Foundation for Prader-Willi Research (FPWR) announced a venture philanthropy investment in ConSynance Therapeutics to support the advancement of CSTI-500, ConSynance s investigational therapy for the treatment of behavioral dysregulation and hyperphagia in PWS

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There was some evidence of publication bias (Egger test, P = 0.94), but the trim-and-fill method indicated that this publication bias did not impact the estimate