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The previous studies also showed that the seed extract of Castanospermum australe possesses very strong DPP-IV inhibitory alkaloids, including castanospermine, 7-deoxy-6-epi-castanospermine, and australine, and these are depicted as their efficacy in the management of hyperglycemia in rats ( Table 3 ( in silico studies performed on the plant Amberboa ramose determined that the compound 5-hydroxy-7,8 dimethoxyflavone can be considered a promising candidate for serving well for all the purposes of drug likeliness by following the Lipinskis rule (140)

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Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)

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