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The Phase 2 Obesity Trial (Jastreboff Et Al., 2023) The obesity trial published in The New England Journal of Medicine was a phase 2, double-blind, randomized study in adults with obesity (and, in a subgroup, obesity with type 2 diabetes) that assigned participants to several ascending retatrutide dose groups or placebo, with gradual dose escalation to manage tolerability, over 48 weeks

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J Physiol Pharmacol 2003, 54, 17-32

By improving metabolic health comprehensively, Retatrutide may succeed where single-target approaches fail, particularly for individuals whose mood issues have a strong metabolic component