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14 Natives or long-term high-altitude sojourners, who are chronically exposed to altitude hypoxia, may develop several altitude-related illnesses, including polycythemia, systemic hypertension, pulmonary hypertension, congenital heart disease, thromboembolic disease, lung disease, mental deterioration, as well as pregnancy and neonatal problems

Over time, as your metabolism adjusts to lower caloric intake and becomes more efficient at accessing fat stores, this effect diminishes

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Data Availability Data sharing is not applicable to this article as no datasets were generated or analysed during the current study

Hydroquinone inhibits tyrosinase through multiple simultaneous mechanisms it interferes with tyrosinase enzyme activity, disrupts melanosome formation, and has direct cytotoxic effects on hyperactive melanocytes