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[41] One possibility is that multiple redox-active flavoproteins all contribute a small portion to the overall production of oxidants under normal conditions

Clin Cancer Res (2012) 18(16):42406

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845 Transcriptomic analyses of patients with intestinal I/R injury and mice showed that ferroptosis-related genes such as IL-6, CXCL2, HMOX1, GDF15, HSPA5, and TNFAIP3, may be hub genes in intestinal I/R injury

These LBM findings have triggered an ongoing scientific debate, with critics worrying that such losses could result from reductions in skeletal muscle mass, thereby leading to frailty, particularly in older adults