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In addition, both uremic controls and rhGH-treated uremic animals showed a significantly increased mean sclerotic index, compared to healthy rats, which was even more pronounced in rhGH-treated animals, suggesting that the beneficial effects of prolonged rhGH-treatment on kidney growth results in progressive glomerulosclerosis in rodents

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206,347 In another study, treatment of primary mouse chondrocytes with liraglutide reduced the mRNA expression levels of iNOS, MMP-13, and ADAMTS5, leading to a decrease in the secretion of inflammatory markers, including NO, prostaglandin E, and IL-6